Intas Nayflee Plus (Fipronil + S-Methoprene) Tick and Flea Spot On for Dogs

Most flea treatments kill the fleas on your dog. Nayflee Plus kills the next generation too.

Intas Nayflee Plus spot on for dogs is a dual-action monthly flea and tick treatment that combines Fipronil 9.8% w/v with (S)-Methoprene 8.8% w/v — an Insect Growth Regulator (IGR) — in a single pipette applied to the back of the neck once a month. Fipronil kills adult fleas, ticks, and lice on contact. S-Methoprene prevents flea eggs and larvae from developing into breeding adults, collapsing the reinfestation cycle before it can restart.

This is the meaningful difference between Nayflee Plus dog spot on and a plain Fipronil spot on for dogs. Plain Fipronil knocks down the adults you can see. Nayflee Plus also neutralises the eggs and larvae developing in your carpets, bedding, and floor cracks that you cannot see — which make up over 95% of a flea infestation at any given time.

Available in 4 sizes to suit every breed — 0.67ml for dogs up to 10kg, 1.34ml for 10 to 20kg, 2.68ml for 20 to 40kg, and 4.02ml for dogs above 40kg. Also indicated for the management of flea allergy dermatitis and acaral lick dermatitis in dogs. From NUVO — A Division of Intas Pharmaceuticals Ltd., Ahmedabad. Safe from 8 weeks of age.

What Does Intas Nayflee Plus Spot On Treat in Dogs?

Here is what Nayflee Plus dog tick flea spot on treats and prevents:

• Flea treatment and lifecycle control — Fipronil kills adult fleas on contact within hours of application. S-Methoprene acts as an IGR, preventing flea eggs and larvae from maturing into breeding adults and breaking the entire flea lifecycle. For dogs with recurring flea problems, this lifecycle-disrupting action is what makes the difference between getting on top of an infestation and chasing it indefinitely

• Tick control — kills ticks that latch onto your dog during walks, outdoor play, or contact with other animals. Monthly application provides up to 4 weeks of residual protection against reinfestation

• Lice control — eliminates sucking and biting lice that cause coat damage, skin irritation, and persistent scratching in dogs

• Flea allergy dermatitis — indicated for the management of flea allergy dermatitis (FAD) in dogs, where hypersensitive dogs develop severe skin reactions to even a single flea bite. Consistent monthly use prevents the flea exposure that triggers FAD flare-ups

• Acaral lick dermatitis — also indicated for acaral lick dermatitis management, where mite activity contributes to compulsive licking and localised skin lesions in dogs

Learn more about ticks and fleas in dogs by reading our expert-approved blog: The Ultimate Remedy for Tick and Flea Removal for Dogs

How Does Fipronil Plus S-Methoprene Work on Parasites?

• Nayflee Plus dog spot on works through two active ingredients targeting completely different life stages of the flea population

• Fipronil is a phenylpyrazole insecticide that blocks GABA-gated chloride channels in the nervous systems of adult fleas, ticks, and lice, causing hyperexcitation, paralysis, and death within hours of contact

• After application, Fipronil spreads across the coat through the sebaceous glands and is continuously released onto the coat surface for up to 4 weeks, providing lasting residual protection well beyond the day of application

• S-Methoprene is a juvenile hormone analogue — it mimics the natural hormone that keeps immature fleas locked in their larval stage, preventing them from completing their development into breeding adults. Flea eggs that fall from the treated dog into the environment and larvae developing in carpets and bedding are unable to mature when exposed to S-Methoprene

• Together, this fipronil methoprene dog spot on combination delivers both immediate adult knock-down and long-term flea lifecycle control in a single monthly application

Which Size of Nayflee Plus Should You Buy for Your Dog?

There are 4 sizes. Weigh your dog before every order:

 

Never use a smaller pipette and apply multiple times to make up the dose — always use the single pipette corresponding to your dog's weight. If your dog is between sizes, go with the larger pipette and consult your vet.

How Do You Apply Nayflee Plus Spot On to Your Dog?

1. Select the correct pipette size for your dog's bodyweight

2. Part the fur at the base of the neck, between the shoulder blades — where your dog cannot reach to lick

3. Snap or twist the pipette tip open

4. For dogs up to 20kg, apply the entire contents directly onto the skin in one spot

5. For dogs above 20kg, apply across 2 to 3 spots along the spine for better distribution

6. Do not rub in — allow the solution to spread naturally through the coat via the sebaceous glands

7. Keep your dog dry and avoid bathing for at least 48 hours after application

8. Apply once every month for continuous protection

If you want a video guide on how to administer the product to your dog, then watch this video

⚠️ Before you use it:

• For dogs and puppies 8 weeks of age and older only

• Apply only where your dog cannot lick — the back of the neck or along the spine

• Wash hands thoroughly after application

• Keep children and other pets away from the treated coat until fully dry

• Do not bathe your dog for 48 hours before or after application

What Are the Side Effects of Nayflee Plus Dog Spot On?

Side effects are uncommon when applied correctly. Here is what to watch for:

• Temporary skin irritation at the application site — mild redness, flaking, or localised hair loss at the spot where the pipette was applied. Usually resolves within a few days without treatment

• Drooling or hypersalivation — rare for dogs compared to cats, but can occur if the dog manages to lick the application site before drying. Monitor after application and prevent licking until dry

• Greasy or clumped fur at application site — the pipette solution may leave a slightly oily patch for 24 to 48 hours. This is normal and not a sign of a reaction

• Lethargy — rare, and usually only associated with licking of the application site or use of an incorrect dose. Contact your vet if your dog seems unusually unwell after application

When Should You Not Use Nayflee Plus Dog Spot On?

Check with your vet before using if:

• Your puppy is under 8 weeks of age

• Your dog is pregnant or nursing — consult your vet before use in breeding animals

• Your dog is unwell or underweight — apply only to healthy animals

• Your dog is already on another ectoparasite treatment — check before combining

⚠️ Clinical Safety Notice:

• Never use the cat-specific Nayflee Plus formulation on your dog — the S-methoprene concentration differs between the cat and dog versions and the pipette sizes are calibrated for species-specific bodyweights. Use specific cat tick & flea solutions

• In multi-pet households, keep your dog separated from other pets until the application site is completely dry to prevent accidental grooming of the treatment site by cats or other dogs

• Keep your dog dry for 48 hours after application — bathing too soon significantly reduces the efficacy of both Fipronil and S-Methoprene

• If your dog shows severe neurological signs after application, contact your vet immediately

How Should You Store Nayflee Plus Spot On?

• Store at room temperature, away from direct sunlight

• Keep in original packaging until use

• Keep out of reach of children and other pets

• Do not freeze

• Check expiry date on packaging before use

What Are the Alternatives to Intas Nayflee Plus Dog Spot On?

 

Always consult your vet before switching spot-on treatments, particularly if your dog has a history of flea allergy dermatitis or is on a concurrent heartworm prevention protocol.

Vet Also Recommends

• Explore our complete Dog Tick & Flea Collection

• Explore our complete Cat Tick & Flea Collection

• Explore our best-selling collection of Pet Dewormers

Keep your dog protected from fleas and ticks year-round — buy Intas Nayflee Plus spot on for dogs online on Supertails. 100% authentic, sourced from authorised distributors. Available in 4 sizes for every breed. Check Nayflee Plus dog spot on price and read reviews from verified buyers on the product page. Same-day delivery available in select cities. Not sure which size is right for your dog? Chat with our in-house vets before you order.

FAQs

What does Intas Nayflee Plus spot on treat in dogs?

Intas Nayflee Plus treats and prevents fleas, ticks, and lice in dogs. It also breaks the flea lifecycle by preventing eggs and larvae from developing into adults — controlling reinfestation, not just the visible infestation. It is additionally indicated for managing flea allergy dermatitis and acaral lick dermatitis. Available in 4 sizes for dogs from under 10kg to above 40kg.

How do I apply Nayflee Plus spot on to my dog correctly?

Choose the correct pipette size for your dog's weight. Part the fur at the base of the neck between the shoulder blades and apply the entire contents directly onto the skin. For dogs above 20kg, spread across 2 to 3 spots along the spine. Do not rub in. Keep your dog dry for 48 hours after application and avoid bathing before and after.

How is Nayflee Plus different from a plain Fipronil spot on for dogs?

Plain Fipronil spot-ons kill adult fleas only. Nayflee Plus adds S-Methoprene, an Insect Growth Regulator that prevents flea eggs and larvae from maturing into breeding adults. Since over 95% of a flea infestation exists as eggs and larvae in the environment rather than adults on the dog, this lifecycle-disrupting action is what prevents reinfestation rather than just temporarily reducing the adult flea population.

Which size of Nayflee Plus should I buy for my dog?

Nayflee Plus comes in 4 sizes: 0.67ml for dogs up to 10kg, 1.34ml for 10 to 20kg, 2.68ml for 20 to 40kg, and 4.02ml for dogs above 40kg. Always weigh your dog before ordering — never estimate. If your dog falls between two sizes, use the larger pipette. Using a pipette that is too small and applying multiple times does not substitute for the correct single-pipette dose.

How often should I use Nayflee Plus spot on on my dog?

Apply once every month for continuous protection. A single application provides up to 4 weeks of residual protection against adult fleas, ticks, and lice, while S-Methoprene continues to suppress flea egg and larval development in your dog's environment. During India's monsoon season when flea and tick activity peaks, consistent monthly application without gaps is essential to stay ahead of reinfestation.