Intas Nayflee Plus (Fipronil + S-Methoprene) Tick and Flea Spot On for Cats

Most cat flea treatments kill the fleas you can see. Nayflee Plus kills the ones you can't yet.

Intas Nayflee Plus spot on for cats is a dual-action monthly spot on that combines two active ingredients — Fipronil 9.8% w/v and (S)-Methoprene 11.8% w/v — to tackle both the adult parasites living on your cat today and the eggs, larvae, and pupae developing in your home right now. Fipronil handles the adults on contact. S-Methoprene, an Insect Growth Regulator (IGR), prevents immature flea stages from developing into breeding adults — breaking the flea lifecycle at the source rather than just knocking down what's visible on the coat.

This is why Nayflee Plus cat spot-on controls reinfestation more effectively than plain Fipronil spot-ons, which address adults only. A single 0.5ml pipette applied to the back of the neck, once a month, provides up to 4 weeks of protection against fleas, ticks, and lice — and is also indicated for the management of flea allergy dermatitis and acaral lick dermatitis in cats.

From Intas Pharmaceuticals Ltd. (PET Division), Ahmedabad, one of India's largest and most trusted pharmaceutical companies. Safe for cats and kittens from 8 weeks of age.

What Does Intas Nayflee Plus Spot On Treat in Cats?

Here is what Nayflee Plus cat tick flea spot on treats and prevents:

• Flea treatment and lifecycle control — Fipronil kills adult fleas on contact within hours of application. S-Methoprene acts as an IGR, preventing flea eggs and larvae from developing into adult fleas. Together they break the entire flea lifecycle, not just the adult stage — this is the critical difference between Nayflee Plus and a plain Fipronil spot on for cats.

• Tick control — kills ticks that attach to your cat during outdoor activity or contact with other animals. Monthly application prevents reinfestation for up to 4 weeks.

• Lice control — eliminates biting lice that cause coat damage, skin irritation, and persistent scratching in cats.

• Flea allergy dermatitis — indicated for the management of flea allergy dermatitis (FAD) in cats, a common condition where hypersensitive cats develop severe skin reactions to even a single flea bite. Consistent monthly use prevents the flea exposure that triggers FAD episodes.

• Acaral lick dermatitis — also indicated for acaral lick dermatitis management, where mite activity contributes to compulsive licking and skin irritation in cats.

Learn more about ticks and fleas in cats by reading our expert-approved blog: Cat Fleas and Ticks: Treatment and Prevention.

How Does Fipronil Plus S-Methoprene Work?

• Nayflee Plus cat spot-on works through two active ingredients with completely different mechanisms, targeting different life stages of fleas

• Fipronil is a phenylpyrazole insecticide that blocks GABA-gated chloride channels in the nervous systems of adult fleas, ticks, and lice, causing hyperexcitation, paralysis, and death on contact within hours of application.

• After application, Fipronil spreads across the coat through the sebaceous glands and is stored there, providing continuous release onto the coat surface for up to 4 weeks.

• S-Methoprene is a juvenile hormone analogue — it mimics the hormone that keeps immature fleas in their larval stage, preventing them from maturing into breeding adults. Flea eggs and larvae exposed to S-Methoprene cannot complete their development, collapsing the next generation of infestation before it starts.

• Because flea eggs fall off into the environment and larvae develop in carpets, bedding, and floor cracks, the IGR component works both on eggs that fall from the treated cat and on larvae in the immediate environment.

• Together, this fipronil methoprene cat spot-on combination provides both immediate knock-down of the adult population and long-term lifecycle disruption.

How Do You Apply Nayflee Plus Spot On to Your Cat?

1. Remove the 0.5ml pipette from its packaging.

2. Part your cat's fur at the base of the neck, between the shoulder blades — the one spot your cat physically cannot reach to groom.

3. Hold the pipette upright, snap or twist the tip open

4. Apply the entire contents directly onto the skin in one spot — do not split across multiple locations

5. Do not rub in — allow the solution to spread naturally through the coat via the sebaceous glands

6. Keep your cat dry and avoid bathing for at least 48 hours after application

7. Apply once every month for continuous protection

For a video guide on how to administer the product to your cat, watch this video

Dosage:

 

⚠️ Before you use it:

• For cats and kittens 8 weeks of age and older only

• Apply only to the back of the neck, where your cat cannot lick — licking before the site dries is the most common cause of adverse reactions.

• Wash your hands thoroughly after application

• Keep children and other pets away from the treated coat until fully dry

• Do not bathe your cat for 48 hours before or after application

What Are the Side Effects of Nayflee Plus Cat Spot On?

Side effects are uncommon when applied correctly. Here is what to watch for:

• Temporary skin irritation at the application site — mild redness, flaking, or localised hair loss at the spot where the pipette was applied. Usually resolves within a few days without intervention.

• Drooling or hypersalivation — occurs when a cat manages to groom the application site before it dries. The solution is bitter-tasting and unpleasant but not dangerous in small amounts. An e-collar for 30 to 60 minutes after application prevents this entirely.

• Greasy or clumped fur at the application site — the pipette solution may leave a slightly oily patch for 24 to 48 hours. This is normal and not a sign of a reaction.

• Lethargy — rare, and usually only associated with licking of the application site. If your cat seems unusually unwell after application, contact your vet.

When Should You Not Use Nayflee Plus Cat Spot On?

Check with your vet before using if:

• Your kitten is under 8 weeks of age

• Your cat is pregnant or nursing — consult your vet before use in breeding animals

• Your cat is unwell or underweight — apply only to healthy animals

• Your cat is already on another ectoparasite treatment — check with your vet before combining

⚠️ Clinical Safety Notice:

• Never use a dog-specific Fipronil spot on your cat. Dog formulations have different concentrations and pipette volumes. Always use the cat-specific Nayflee Plus pipette. Use dog-specific tick & flea remedies

• Licking of the application site is the most common cause of adverse reactions in cats. Fit an e-collar for 30 to 60 minutes after application if your cat is likely to groom immediately.

• In multi-pet households, keep cats separated from other pets until the application site is completely dry.

• If your cat shows severe neurological signs — tremors, loss of coordination, or collapse — after application, contact your vet immediately.

How Should You Store Nayflee Plus Spot On?

• Store at room temperature, away from direct sunlight

• Keep in original packaging until use

• Keep out of reach of children and other pets

• Do not freeze

• Check the expiry date on the packaging before use

What Are the Alternatives to Intas Nayflee Plus Cat Spot On?

 

Always consult your vet before switching spot-on treatments, particularly if your cat has a history of flea allergy dermatitis.

Vet Also Recommends

• Explore our complete range of Cat Tick & Flea remedies

• Explore our complete range of Dog Tick & Flea remedies

• Explore our best-selling Pet Dewormers on Supertails

Keep your cat protected from fleas and ticks year-round — buy Intas Nayflee Plus spot on for cats online on Supertails. 100% authentic, sourced from authorised distributors. Check Nayflee Plus cat spot on price and read reviews from verified buyers on the product page. Same-day delivery available in select cities. Not sure if Nayflee Plus is the right choice for your cat? Chat with our in-house vets before you order.

FAQs

What does Intas Nayflee Plus spot on treat in cats?

Intas Nayflee Plus treats and prevents fleas, ticks, and lice in cats. It also breaks the flea lifecycle by killing eggs and larvae before they develop into adults — preventing reinfestation, not just treating the visible infestation. It is additionally indicated for managing flea allergy dermatitis and acaral lick dermatitis in cats. Safe for cats and kittens from 8 weeks of age.

How do I apply Nayflee Plus spot-on to my cat correctly?

Part the fur at the base of the neck between the shoulder blades. Apply the entire 0.5ml pipette directly onto the skin in one spot. Do not rub in. Keep the site dry for 48 hours and avoid bathing before or after application. Fit an e-collar for 30 to 60 minutes after applying — cats frequently attempt to groom the back of their neck, and licking the site before it dries causes drooling.

How is Nayflee Plus different from a plain Fipronil spot-on for cats?

Plain Fipronil spot-ons kill adult fleas only. Nayflee Plus adds S-Methoprene, an Insect Growth Regulator that prevents flea eggs and larvae from maturing into breeding adults. This breaks the entire flea lifecycle rather than just knocking down the adult population. For cats with recurring flea problems or flea allergy dermatitis, this lifecycle-disrupting action is what makes the meaningful difference.

How often should I use Nayflee Plus spot on on my cat?

Apply once every month for continuous protection. A single application provides up to 4 weeks of protection against adult fleas, ticks, and lice, while the IGR component continues to suppress egg and larval development in the environment. During peak flea season — India's monsoon months, particularly — consistent monthly application without gaps is the most effective way to prevent reinfestation.

Is Nayflee Plus spot on safe for kittens?

Yes — Nayflee Plus is safe for kittens from 8 weeks of age. Do not use on kittens under 8 weeks. One 0.5ml pipette covers cats and kittens of all weights up to 10kg. If your kitten is very young or unwell, check with your vet before applying. Always apply at the base of the neck where the kitten cannot groom, and monitor for 30 to 60 minutes after application.